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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRKAR1A All Species: 43.94
Human Site: S238 Identified Species: 69.05
UniProt: P10644 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P10644 NP_002725.1 381 42982 S238 Y R R I L M G S T L R K R K M
Chimpanzee Pan troglodytes XP_511647 260 29299 R146 S H L D D N E R S D I F D A M
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_537577 381 43019 S238 Y R R I L M G S T L R K R K M
Cat Felis silvestris
Mouse Mus musculus Q9DBC7 381 43167 S238 Y R R I L M G S T L R K R K M
Rat Rattus norvegicus P09456 381 43076 S238 Y R R I L M G S T L R K R K M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509586 626 69567 S483 Y R R I L M G S T L R K R K M
Chicken Gallus gallus Q5ZM91 382 43332 S239 Y R R I L M G S T L R K R K M
Frog Xenopus laevis NP_001085084 381 43157 S238 Y R R I L M G S T L R K R K M
Zebra Danio Brachydanio rerio NP_001017732 379 43009 S236 Y R R I L M G S T L R K R K M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P16905 376 42221 S233 Y R R I L M G S T I R K R K M
Honey Bee Apis mellifera XP_396167 372 41646 I246 E F L S R V S I L E S L D K W
Nematode Worm Caenorhab. elegans P30625 366 41449 L235 R K M Y D E F L S K V Q I L A
Sea Urchin Strong. purpuratus Q26619 369 41770 L243 K V S I F K S L E P Y E R M N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P07278 416 47201 S285 F R K I L L G S S F K K R L M
Red Bread Mold Neurospora crassa Q01386 385 42138 S244 F R R I L M E S T F S R R R M
Conservation
Percent
Protein Identity: 100 68.2 N.A. 97.9 N.A. 96.8 97.3 N.A. 58.7 92.4 92.6 91.5 N.A. 71.3 74 57.7 39.3
Protein Similarity: 100 68.2 N.A. 98.1 N.A. 97.3 98.4 N.A. 60 96 95.8 95.8 N.A. 81.6 85.3 73.4 56.9
P-Site Identity: 100 6.6 N.A. 100 N.A. 100 100 N.A. 100 100 100 100 N.A. 93.3 6.6 0 13.3
P-Site Similarity: 100 13.3 N.A. 100 N.A. 100 100 N.A. 100 100 100 100 N.A. 100 13.3 20 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 31.2 34
Protein Similarity: N.A. N.A. N.A. N.A. 50.7 52.4
P-Site Identity: N.A. N.A. N.A. N.A. 53.3 60
P-Site Similarity: N.A. N.A. N.A. N.A. 86.6 80
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 7 14 0 0 0 0 7 0 0 14 0 0 % D
% Glu: 7 0 0 0 0 7 14 0 7 7 0 7 0 0 0 % E
% Phe: 14 7 0 0 7 0 7 0 0 14 0 7 0 0 0 % F
% Gly: 0 0 0 0 0 0 67 0 0 0 0 0 0 0 0 % G
% His: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 80 0 0 0 7 0 7 7 0 7 0 0 % I
% Lys: 7 7 7 0 0 7 0 0 0 7 7 67 0 67 0 % K
% Leu: 0 0 14 0 74 7 0 14 7 54 0 7 0 14 0 % L
% Met: 0 0 7 0 0 67 0 0 0 0 0 0 0 7 80 % M
% Asn: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 7 % N
% Pro: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % Q
% Arg: 7 74 67 0 7 0 0 7 0 0 60 7 80 7 0 % R
% Ser: 7 0 7 7 0 0 14 74 20 0 14 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 67 0 0 0 0 0 0 % T
% Val: 0 7 0 0 0 7 0 0 0 0 7 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % W
% Tyr: 60 0 0 7 0 0 0 0 0 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _